Study On The Cellular Regulation And Function Of Lysine Malonylation, Glutarylation And Crotonylatio

The understanding of the mechanism driving this solidification is, however, still limited, especially for the important transient stage while the response develops as a function of time. Most remarkable is the highly counter-intuitive ability of concentrated suspensions to strongly thicken and even solidify when sheared or impacted. In this thesis, high-speed ultrasound imaging is introduced to track, for the first time, the transition from the flowing to the solidified state and directly observe the shock-like shear fronts that accompany this transition.

A model is developed that agrees quantitatively with the experimental measurements.The understanding of the mechanism driving this solidification is, however, still limited, especially for the important transient stage while the response develops as a function of time.

This thesis demonstrates the first use of high-speed ultrasound imaging to non-invasively probe how the interior of a dense suspension responds to impact. Most remarkable is the highly counter-intuitive ability of concentrated suspensions to strongly thicken and even solidify when sheared or impacted..

It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr.Taken together, these studies provide information critical to understanding how these protein PTMs are associated with various human diseases, and to identifying therapeutic targets for the dysregulation of these novel protein markers in various human diseases. This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr)..

. This book presents pioneering findings on the characterization of cellular regulation and function for three recently identified protein posttranslational modifications (PTMs): lysine malonylation (Kmal), glutarylation (Kglu) and crotonylation (Kcr).

It focuses on the theoretical understanding of the salient features of plasmons in nanosystems as well as on the multifaceted aspects of plasmon-enhanced light–matter interactions at the nanometer scale.

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. These contributions constitute novel and solid advancements in the research field of plasmonics and nanophotonics that will help guide future experimental investigations in the blossoming field of nanophotonics, and also facilitate the design of the next generation of truly nanoscale nanophotonic devices. Special emphasis is given to the modeling of nonclassical behavior across the transition regime bridging the classical and the quantum domains.Plasmonics and Light–Matter Interactions in Two-Dimensional Materials and in Metal Nanostructures The research presented in this dissertation provides useful tools for understanding surface plasmons in various two- and three-dimensional nanostructures, as well as quantum mechanical effects in their response and their joint impact on light–matter interactions at the extreme nanoscale.

It addresses three main topics: (i) Detecting Kmal substrates using a chemical reporter, which provides important information regarding the complex cellular networks modulated by Kmal; (ii) Identifying Kglu as a new histone PTM and assessing the direct impact of histone Kglu on chromatin structure and dynamics; and (iii) Revealing Sirt3’s value as a regulating enzyme for histone Kcr dynamics and gene transcription, which opens new avenues for examining the physiological significance of histone Kcr.

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