The Genetic Basis Of Male Infertility

This book covers the structures and postulated functions for the major classes of mammalian carbohydrate binding proteins.These include intracellular lectins involved in diverse functions such as protein synthesis quality control, targetting of lysosomal enzymes and in the secretory pathway. In the last decade there has been a great expansion in our knowledge of the existence, nature and functions of mammalian carbohydrate binding proteins.

This is most dramatically apparent during early stages of development, when new types of cells and organs are being formed, often during very short time spans. Indeed, it is now wellknown that the propen­ sity for a gene to be transcribed or silenced is stably propagated through many cell generations, even from parent to progeny.

Further, mechanistic aspects of cell death and role of apoptosis in disease is covered. The past few years have seen rapid progress in apoptosis research.

In the subsequent years more then 10 such disease genes have been identified. Trinu­ cleotide repeat diseases are ideal subjects for direct testing because the muta­ tion is almost exclusively of the same type and there is an extremely low occur­ ance of new mutations in these diseases. The discovery in 1991 that human disease can be caused by large-scale ex­ pansion of highly unstable trinucleotide repeats has elucidated a new mutation mechanism, heritable unstable DNA. The identification of repeat instability and the identification of disease genes containing trinucleotide repeats has helped to answer intriguing questions.

While some chapters review the body of knowledge of the subject, others contain new experimental data.Each section includes an historical perspective and a detailed commentary on actin protein chemistry, molecular and cell biology of actin. Actin Structure and Actin-Binding Proteins") provide an authoritative and opinionated view of the structure and function of this essential protein.

plays an essential role in normal cell physiology and that aberrant apoptosis can manifest itself in a variety of human disorders.

Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility. This volume explores recent progress in the understanding of the genetics of spermatogenesis and male infertility.

.This book presents a comprehensive and up-to-date account of research on the effect of elevated temperature on developmental programs and on the possible roles of heat shock proteins in normal development in animals and plants.

Topics include fundamental advances and current problems in the development and function of the testis, an outline of clinical findings in male infertility and an overview of the role of the Y chromosome in male fertility.

.This book presents a comprehensive and up-to-date account of research on the effect of elevated temperature on developmental programs and on the possible roles of heat shock proteins in normal development in animals and plants.