Tubulin-Binding Agents

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There is currently no description available.

There is currently no description available.

Without discussing this aspect in detail it is obvious that today a renaissance of sophis­ ticated solution phase synthesis can be noted.. Over the last decade the environmental setup has changed for synthetic organ­ ic chemists to a considerable degree. These ought to be able to perform preferentially highly selective (chemo-, regio-and stereose­ lective) synthetic transformations, often applied in the context of complex and highly functionalized molecules.

There is currently no description available.

There is currently no description available.

The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5).

The authors of the two chapters discuss critically the advantages and limitations of each methodology.Both NMR and EM models are, however, able to explain a consistent set of SAR data. The SAR data are discussed in light of the structural information available for each agent. A comprehensive survey of the synthetic chemistry efforts of several groups over a 14-year period is provided together with a compa- son of the different approaches.

The authors of the two chapters discuss critically the advantages and limitations of each methodology.Both NMR and EM models are, however, able to explain a consistent set of SAR data. Thermodynamic, kinetic, structural and fu- tional data on microtubules stabilizing drugs are discussed in an interdisciplinary manner to generate a “time-resolved” picture of the interaction of the drugs with different tubulin forms. The fourth and fifth chapters review the efforts and achievements made in the characterization of the structure of the complexes of tubulin with microtubules stabilizing agents by NMR (Chapter 4) and EM (Chapter 5).

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